An attending general surgeon at Seattle Grace hospital, Miranda Bailey initially gave a cold, domineering impression, earning her the nickname The Nazi. However her attitude has since softened and she has developed a maternal role towards the Residents in the hospital. She has recently undergone a divorce which led her to turn down a fellowship in pediatric surgery.
Preston Burke Isaiah Washington 1, 2, 3 -
Preston Burke was a former Head of Cardiothoracic Surgery. He began a romantic relationship with Cristina Yang, which came under strain when Burke was shot and his right hand's nerve supply was disrupted. With his career threatened he had Yang perform some of his surgeries, a situation which resolved when Derek Shepherd repaired Burke's nerve supply. Burke and Yang continued their relationship which ultimately ended on their Wedding Day, when Burke left Yang at the altar.
Alexandra 'Lexie' Grey Chyler Leigh 4, 5, 6 3
Resident and half-sister of Meredith Grey, Lexie was in a long term relationship with Mark Sloan. Known for her photographic memory, she has earned the nickname Lexiepedia. Initially she had a distant, contentious relationship with Meredith, but they have since grown closer. She is often called "Little Grey" by other doctors on staff.